全文获取类型
收费全文 | 1206篇 |
免费 | 68篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 44篇 |
妇产科学 | 36篇 |
基础医学 | 59篇 |
口腔科学 | 18篇 |
临床医学 | 84篇 |
内科学 | 364篇 |
皮肤病学 | 19篇 |
神经病学 | 42篇 |
特种医学 | 18篇 |
外科学 | 435篇 |
综合类 | 12篇 |
预防医学 | 11篇 |
眼科学 | 60篇 |
药学 | 33篇 |
中国医学 | 1篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 7篇 |
2022年 | 14篇 |
2021年 | 24篇 |
2020年 | 12篇 |
2019年 | 14篇 |
2018年 | 26篇 |
2017年 | 25篇 |
2016年 | 48篇 |
2015年 | 51篇 |
2014年 | 77篇 |
2013年 | 63篇 |
2012年 | 83篇 |
2011年 | 75篇 |
2010年 | 55篇 |
2009年 | 48篇 |
2008年 | 78篇 |
2007年 | 86篇 |
2006年 | 80篇 |
2005年 | 78篇 |
2004年 | 79篇 |
2003年 | 80篇 |
2002年 | 48篇 |
2001年 | 32篇 |
2000年 | 16篇 |
1999年 | 12篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 5篇 |
1985年 | 1篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1973年 | 3篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1279条查询结果,搜索用时 15 毫秒
21.
Ethem Kavukcu Melahat Akdeniz Hasan Huseyin Avci Mehmet Altuğ Mehmet Öner 《Postgraduate medicine》2015,127(1):22-26
Objective: The majority of patients with chronic noncancer pain (CNCP) are managed in the primary care settings. The primary care family physician (PCFP) generally has limited time, training, or access to resources to effectively evaluate and treat these patients, particularly when there is the added potential liability of prescribing opioids. The aim of this study is to make a favorable change in PCFPs’ knowledge, attitudes, and practices about opioid use in CNCP via education on assessment of the risk of opioid misuse. Materials and methods: The universe of this cross-sectional study comprised 36 family physicians working at Family Health Centers affiliated to Antalya Provincial Directorate of Health who volunteered to participate in the study. Initially, a survey on patients risk assessment was performed in both intervention and control groups; whereas the intervention group received education on assessment of the risk of opioid misuse, the control group did not. The survey was repeated after 6 months and the intervention group underwent a core examination. Data obtained were analyzed with Statistical Package for the Social Sciences 18.0 statistics program. Intervention and control groups were compared. Additionally, pre- and post-education results of the intervention group were also compared. Results: About 61.1% of family physicians reported concern and hesitation in prescribing opioids due to known risks, such as overdose, addiction, dependence, or diversion, and agreed that family physicians should apply risk assessment before opioid use in CNCP. Only 16.6% of PCFP reported that risk assessment is not so necessary, whereas 22.2% of PCFP were undecided. Although 47.2% of the family physicians expressed a willingness to apply risk assessment before starting opioids, the rate of eagerness increased markedly to 77.7% after the education, but the rate of increase in practicing was not statistically significant. Conclusion: Knowledge and competency of the family physicians in managing CNCP were improved as was expected. Although the rate of eagerness about risk assessment of opioid misuse was increased, expected increase in the rate of using risk assessment was not achieved. Further studies are needed to identify the reasons of the difficulties on changing the attitudes and practices of primary care physicians about this subject. 相似文献
22.
23.
P-wave dispersion in patients with stable coronary artery disease and its relationship with severity of the disease 总被引:7,自引:0,他引:7
AIM: P-wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. The purpose of this study was to investigate the PD in patients with stable coronary artery disease (CAD) and to determine its relationship with severity of the disease. METHODS: We prospectively analyzed 66 subjects with normal coronary angiogram (group 1) and 68 patients with significant (> or =50%) coronary stenosis; 25 had 1-vessel disease (group 2), 27 had 2-vessel disease (group 3), and 16 had 3-vessel disease (group 4). The maximum and minimum P-wave duration (Pmax and Pmin) and PD were measured from the 12-lead surface electrocardiogram. Echocardiographic examination was also performed. Angiographic vessel score and Gensini score were used to evaluate the severity of CAD. RESULTS: Pmax was longer in groups 3 and 4 compared with group 1 (P = .001 for both comparison). PD was greater in groups 2, 3, and 4 compared with group 1 ( P < .001 for all comparison), and also in group 4 compared with group 2 (P = .001). However, there was no statistically significant difference among the groups regarding Pmin. In bivariate correlation, increased PD was correlated with presence of hypertension (r = 0.278, P = .013), left ventricular ejection fraction (r = -0.231, P = .044), left atrial diameter (r = 0.223, P = .032), presence of moderate to severe mitral regurgitation (r = 0.284, P = .017), vessel score (r = 0.465, P < .001), and Gensini score (r = 0.338, P = .005). Multiple linear regression analysis showed that only vessel score was independently associated with PD (beta = .471, P = .01). CONCLUSIONS: PD was found to be greater in patients with stable CAD than in controls and to be associated with severity of the disease. 相似文献
24.
Background
The Surgical Care Improvement Project (SCIP) includes recommendations for mechanical and pharmacologic venous thromboembolism (VTE) prophylaxis after colorectal surgery. Compliance with these recommendations is publicly reported and included in current pay for performance plans. Presently, there is limited evidence to support compliance with these recommendations.Aim
To determine the incidence of venous thromboembolic events in colorectal surgery patients who did or did not receive the recommended pharmacologic prophylaxis.Methods
We performed a retrospective analysis of prospectively accrued data from a single-center, tertiary care, colorectal surgery department. The main outcome measure was the occurrence of venous thromboembolic events and the need for blood transfusion after surgery.Results
Of 674 patients, 613(91 %) received the recommended pharmacologic VTE prophylaxis and 61 (9 %) did not. Diagnosis, patient variables, and type of surgery performed were similar in each group while operative time was increased in the compliant group (251 vs. 194 min, p < 0.05). In the compliant and noncompliant groups, the incidence of extremity deep venous thrombosis was 2.8 and 8.2 % (p = 0.04), the incidence of pulmonary embolus 1.1 and 3.3 % (p = 0.19), the incidence of portomesenteric venous thrombosis 2.6 and 4.9 % (p = 0.38), and the incidence of any VTE 5.4 and 13.1 % (p = 0.02), respectively. The use of perioperative red blood cell transfusions in the two groups was 9.1 and 14.8 %, p = 0.17. In the subgroup analysis of open cases, there were no statistical differences in the occurrence of any type or combination of VTE.Conclusions
Compliance with SCIP recommendations for pharmacologic VTE prophylaxis decreased the incidence of VTE after colorectal surgery with no increase in the use of perioperative transfusion. Colorectal surgeons who elect to skip these recommendations may jeopardize both the reputational score and financial reimbursement of their hospital and may put their patients at unnecessary risk for a preventable postoperative complication. 相似文献25.
26.
27.
28.
The aim of this retrospective study is to determine the frequency, type, microbiological characteristics and outcome of HAIs in the elderly (age ≥ 65) and to compare the data with younger patients in a Turkish Training and Research Hospital. From January 2008 to December 2009, the infection control team analyzed HAIs among 60,585 hospitalized patients (20,109 aged ≥ 65 and 40,747 aged between 18 and 64 years) with a total number of 419,017 patient days. A total of 825 HAIs episodes were detected in 607 patients, of which 395 episodes were in 301 elderly patients. The incidence of HAIs per 1000 patient days was 2.49 in the elderly and 1.64 in the younger patients’ group (p < 0.001). The most common site of infection in the elderly patients was the urinary tract, whereas in non-elderly group this was the lower respiratory tract. The incidence density of urinary tract infections, respiratory tract infections, surgical site, skin and soft tissue infections, primary bacteremia, and prosthesis infections were significantly higher in the elderly group (p < 0.05). Gram-negative species were the most frequently isolated agents in both groups. There were no significant differences between the groups in the frequency of isolated pathogens or antibiotic susceptibility patterns. Overall, the fatality rate was found 16.8%. The elderly patients were more likely to have crude mortality rates (22% vs. 12%; p < 0.01). The death was most often related to pneumonia, primary bacteremia or intravascular catheter infections in both groups. 相似文献
29.
Oymak Y Dodurga Y Turedi A Yaman Y Ozek G Carti O Gunes BT Erbudak E Berber E Avci CB Vergin C 《Acta haematologica》2012,128(2):73-76
Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis. 相似文献
30.
Pinar Avci MD Theodore T. Nyame MD Gaurav K. Gupta MD PhD Magesh Sadasivam MTech Michael R. Hamblin PhD 《Lasers in surgery and medicine》2013,45(6):349-357